ABSTRACT
Although there was confliction regarding the association of raised anticardiolipin antibodies [ACL] level with renal disease in systemic lupus erythematosus [SLE], the role of B2glycoprotein as a cofactor for ACL binding is established.The presence of ACL and anti-B2GPI may be directly involved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetal loss, thrombocytopenia and thrombosis. To study the possible association between some auto antibodies with the most common clinical complication of disease. The study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25 healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP. Although there was no significant difference in mean concentrations of ACL and anti- B2GP between lupus nephritis and without nephritis [P>0.05], lupus nephritis patients were more likely positive for ACL. Positivity of 100% For ACL and anti-_B2GPwere detected in thrombotic complication, in fetal loss complication patients more likely to be positive for ACL [75%], anti-B2GP [50%], in thrombocytopenia positivity of ACL and anti-B2GP [75%]. There was no association between anti-B2GP and renal disease and presence of both ACL and anti-B2GP carry higher risk for thrombosis and recurrent fetal loss